聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物、其制备方法及水凝胶

Poly(gamma-propynyl-L-glutamate) block copolymer and preparation method and hydrogel thereof

Abstract

本发明提供了一种聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物,包含式(I)结构所示的A嵌段和式(II)结构所示的B嵌段:所述聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物为AB嵌段构型的嵌段共聚物,其中,A嵌段的数均分子量为550~10000,B嵌段的数均分子量为800~20000,B嵌段占所述嵌段共聚物的重量百分数为25%~75%。本发明还提供了一种聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物的制备方法和聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物水凝胶。与现有技术相比,本发明提供的嵌段共聚物中含有丙炔基,从而能够扩大嵌段共聚物的应用范围。
The invention provides poly(gamma-propynyl-L-glutamate) block copolymer. The block copolymer contains a block A shown in the formula (I) and a block B shown in the formula (II). The poly(gamma-propynyl-L-glutamate) block copolymer is AB block copolymer, wherein the number average molecular weight of the block A is 550-10000, the number average molecular weight of the block B is 800-20000, and the weight percentage of the block B to the block copolymer is 25%-75%. The invention also provides a preparation method of the poly(gamma-propynyl-L-glutamate) block copolymer and poly(gamma-propynyl-L-glutamate) block copolymer hydrogel. Compared with the prior art, the block copolymer provided by the invention contains propynyl, thus the application range of the block copolymer can be expanded.

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Patent Citations (1)

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NO-Patent Citations (1)

    Title
    AMANDA C.ENGLER,ET.AL.: "High efficient"grafting onto"a polypeptide backbone using click chemistry", 《ANGEWANDTE CHEMIE INTERNATIONAL EDITION》, vol. 48, no. 49, 9 November 2009 (2009-11-09), pages 9334 - 9338, XP008155217, DOI: doi:10.1002/anie.200904070

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